Turning ‘Cold’ tumors ‘Hot’: immunotherapies in sarcoma

Immunotherapies in sarcoma: Updates and future perspectives

Sarcomas are malignant tumors that are characterized by a wide diversity of subtypes with various cytogenetic profiles. Despite major treatment breakthroughs, standard treatment modalities combining chemotherapy, radiotherapy, and surgery failed to improve overall survival. Therefore, high expectations are foreseen with immunotherapy upon its maturation and better understanding of its mechanism...

Hot Topics in Cold Gases

Since the first experimental realization of Bose-Einstein condensation in cold atomic gases in 1995 there has been a surge of activity in this field. Ingenious experiments have allowed us to probe matter close to zero temperature and reveal some of the fascinating effects quantum mechanics has bestowed on nature. It is a challenge for mathematical physicists to understand these various phenomen...

Cold and hot.

Hot & Cold Working

Q.1. What is hot working ? State its principles, advantages and disadvantages. Ans. Mechanical working of metals above its recrystallisation temperature is known as hot working. Advantages : 1. Larger deformation can be accomplished and more rapidly by hot working since the metal is in plastic state. 2. Porosity of the metal is considerably minimised. 3. Concentrated impurities, if any in the m...

Head and Neck Tumors: Management of Primary Undifferentiated Pleomorphic Sarcoma

Introduction: Sarcomas account for 1% of all tumors originated in the head and neck regions in adults. They constitute a heterogeneous group of tumors of mesenchymal origin with multiple histological variants. The undifferentiated pleomorphic sarcoma (UPS) subtype is the most frequent variant with an incidence range of 2.7-38%.   Materials and Methods: This retrospective...